We illustrate the qualitative improvements offered by GC-LDA in terms of the types of topics extracted with alternative spatial representations, as well as the model's ability to incorporate a-priori knowledge from the neuroimaging

Rhetorical modes are useful in both academic and non-academic writing, and can be subjects to be studied within linguistic research and computational modeling. Establishing a conceptual bridge among these domains could enable each to benefit from the others. This paper proposes duality-based mode operations (split-unite, forward-backward, expansion-reduction and orthogonal dualities) to expand the set of rhetorical modes, introducing generated modes like combination and generalization, thereby enhancing epistemic diversity across multiple applications. It further presents a pyramid multilayer mapping framework (e.g., three layers from the rhetorical model layer, to cognitive layer, and to epistemic layers) that reduces the resulting cognitive complexity. The degrees of expressive diversity and complexity reduction are quantified through binomial combinatorics and Shannon entropy analysis. A Marginal Rhetorical Bit (MRB) is identified, permitting the definition of a rhetorical-scalable parameter that measures expressive growth speed in bits per stage. A direct entropy measure shows that hierarchical selection over smaller subsets markedly reduces choice uncertainty compared with flat selection across all modes. These considerations appear to transform static and non-measurable rhetorical taxonomies into more dynamic and more measurable systems for discourse design. From this work, it would be possible to identify a pathway for future AI systems to operate not only on language tokens but on layered rhetorical reasoning structures, bridging linguistic, pedagogical, academic, and computational research

Physical activity is a modifiable lifestyle factor with potential to support cognitive resilience. However, the association of moderate-to-vigorous physical activity (MVPA) intensity, and timing, with cognitive function and region-specific brain structure remain poorly understood. We analyzed data from 45,892 UK Biobank participants aged 60 years and older with valid wrist-worn accelerometer data, cognitive testing, and structural brain MRI. MVPA was measured both continuously (mins per week) and categorically (thresholded using >=150 min/week based on WHO guidelines). Associations with cognitive performance and regional brain volumes were evaluated using multivariable linear models adjusted for demographic, socioeconomic, and health-related covariates. We conducted secondary analyses on MVPA timing and subgroup effects. Higher MVPA was associated with better performance across cognitive domains, including reasoning, memory, executive function, and processing speed. These associations persisted in fully adjusted models and were higher among participants meeting WHO guidelines. Greater MVPA was also associated with subcortical brain regions (caudate, putamen, pallidum, thalamus), as well as regional gray matter volumes involved in emotion, working memory, and perceptual processing. Secondary analyses showed that MVPA at any time of day was associated with cognitive functions and brain volume particularly in the midday-afternoon and evening. Sensitivity analysis shows consistent findings across subgroups, with evidence of dose-response relationships. Higher MVPA is associated with preserved brain structure and enhanced cognitive function in later life. Public health strategies to increase MVPA may support healthy cognitive aging and generate substantial economic benefits, with global gains projected to reach USD 760 billion annually by 2050.

Large Language Models (LLMs) have reshaped our world with significant advancements in science, engineering, and society through applications ranging from scientific discoveries and medical diagnostics to Chatbots. Despite their ubiquity and utility, the underlying mechanisms of LLM remain concealed within billions of parameters and complex structures, making their inner architecture and cognitive processes challenging to comprehend. We address this gap by adopting approaches to understanding emerging cognition in biology and developing a network-based framework that links cognitive skills, LLM architectures, and datasets, ushering in a paradigm shift in foundation model analysis. The skill distribution in the module communities demonstrates that while LLMs do not strictly parallel the focalized specialization observed in specific biological systems, they exhibit unique communities of modules whose emergent skill patterns partially mirror the distributed yet interconnected cognitive organization seen in avian and small mammalian brains. Our numerical results highlight a key divergence from biological systems to LLMs, where skill acquisition benefits substantially from dynamic, cross-regional interactions and neural plasticity. By integrating cognitive science principles with machine learning, our framework provides new insights into LLM interpretability and suggests that effective fine-tuning strategies should leverage distributed learning dynamics rather than rigid modular interventions.

-- Despite extensive research on the relationship between sleep and cognition, the connection between sleep microstructure and human performance across specific cognitive domains remains underexplored. This study investigates whether deep learning models can predict executive functions, particularly cognitive adaptability and conceptual reasoning from physiological processes during a night's sleep. T o address this, we introduce CogPSGFormer, a multi-scale convolutional-transformer model designed to process multi-modal polysomno-graphic data. This model integrates one-channel ECG and EEG signals along with extracted features, including EEG power bands and heart rate variability parameters, to capture complementary information across modalities. A thorough evaluation of the CogPSGFormer architecture was conducted to optimize the processing of extended sleep signals and identify the most effective configuration. The proposed framework was evaluated on 817 individuals from the ST AGES dataset using cross-validation. The model achieved 80.3% accuracy in classifying individuals into low vs. high cognitive performance groups on unseen data based on Penn Conditional Exclusion T est (PCET) scores. I. INTRODUCTION Cognitive decline linked to changes in sleep characteristics--such as variations in sleep architecture, quality, and duration--represents a significant global health challenge.

Continual Learning of Multiple Cognitive Functions with Brain-inspired Temporal Development Mechanism Bing Han 1, 3,#, Feifei Zhao 1, #, Yinqian Sun 1, Wenxuan Pan 1,3, Yi Zeng 1, 2,3,4, 1 Brain-inspired Cognitive Intelligence Lab, Institute of Automation,Chinese Academy of Sciences 2 State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Chinese Academy of Sciences 3 School of Artificial Intelligence, University of Chinese Academy of Sciences 4 Center for Long-term Artificial Intelligence Corresponding authors: yi.zeng@ia.ac.cn # Co-first authors with equal contribution April 9, 2025 Abstract Cognitive functions in current artificial intelligence networks are tied to the exponential increase in network scale, whereas the human brain can continuously learn hundreds of cognitive functions with remarkably low energy consumption. This advantage is in part due to the brain's cross-regional temporal development mechanisms, where the progressive formation, reorganization, and pruning of connections from basic to advanced regions, facilitate knowledge transfer and prevent network redundancy. Inspired by these, we propose the Continual Learning of Multiple Cognitive Functions with Brain-inspired Temporal Development Mechanism(TD-MCL), enabling cognitive enhancement from simple to complex in Perception-Motor-Interaction(PMI) multiple cognitive task scenarios. The TD-MCL model proposes the sequential evolution of long-range connections between different cognitive modules to promote positive knowledge transfer, while using feedback-guided local connection inhibition and pruning to effectively eliminate redundancies in previous tasks, reducing energy consumption while preserving acquired knowledge. Experiments show that the proposed method can achieve continual learning capabilities while reducing network scale, without introducing regularization, replay, or freezing strategies, and achieving superior accuracy on new tasks compared to direct learning. The proposed method shows that the brain's developmen-1 arXiv:2504.05621v1 Keywords Brain-inspired Temporal Development, Multiple Cognitive Functions Continual Learning, Evolutionary Growth Long-range Connectivity, Feedback-guided Suppression and Pruning, Biological Synaptic Plasticity 1 Introduction Artificial intelligence algorithms have achieved remarkable success across various fields, but their enhancement of cognitive functions relies on the massive stacking of parameters, often facing challenges in balancing memory capacity with energy consumption[1]. In contrast, the brain requires only 20 watts of power to gradually master a rich array of cognitive functions during its developmental process, offering valuable biological insights.

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in estimating the health effects of air pollution and its constituents, especially when evaluating the causal effects of correlated multi-pollutant constituents measured with correlated error. This paper addresses estimation and inference for the causal effect of one constituent in the presence of other PM2.5 constituents, accounting for measurement error and correlations. We used a linear regression calibration model, fitted with generalized estimating equations in an external validation study, and extended a double/debiased machine learning (DML) approach to correct for measurement error and estimate the effect of interest in the main study. We demonstrated that the DML estimator with regression calibration is consistent and derived its asymptotic variance. Simulations showed that the proposed estimator reduced bias and attained nominal coverage probability across most simulation settings. We applied this method to assess the causal effects of PM2.5 constituents on cognitive function in the Nurses' Health Study and identified two PM2.5 constituents, Br and Mn, that showed a negative causal effect on cognitive function after measurement error correction.

What is the "nature" of the cognitive processes and contents of an artificial neural network? In other words, how does an artificial intelligence fundamentally "think," and in what form does its knowledge reside? The psychology of artificial intelligence, as predicted by Asimov (1950), aims to study this AI probing and explainability-sensitive matter. This study requires a neuronal level of cognitive granularity, so as not to be limited solely to the secondary macro-cognitive results (such as cognitive and cultural biases) of synthetic neural cognition. A prerequisite for examining the latter is to clarify some epistemological milestones regarding the cognitive status we can attribute to its phenomenology.

There are nearly seven million people currently diagnosed with Alzheimer's in the US, and while there is no cure, experts are searching for ways to prevent it. That is because stories about far off lands and mythical creatures require readers to remember what happened early on in the book to understand the ending. 'Fiction may elicit more intense emotions and imagery in addition to new facts and ideas from reading non-fiction books,' said Dr. Zaldy Tan, a professor of neurology and medicine at Cedars-Sinai Medical Center. 'But more than the type of book, the key here is sustainability, Tan said, adding: 'I recommend people challenge their minds by reading something new to them.' Alzheimer's disease is the sixth leading cause of death in the US with 6.9 million people living with the disease which is expected to double by 2050 Neuroscientists have suggested that remaining physically active and engaging in other activities like knitting, playing chess and puzzles and gardening could also prevent cognitive decline. 'Leisure activities including reading have been associated with lower risk of developing dementia in older adults,' Tan told DailyMail.com.

The conventional wisdom of manifold learning is based on nonlinear dimensionality reduction techniques such as IsoMAP and locally linear embedding (LLE). We challenge this paradigm by exploiting the blessing of dimensionality. Our intuition is simple: it is easier to untangle a low-dimensional manifold in a higher-dimensional space due to its vastness, as guaranteed by Whitney embedding theorem. A new insight brought by this work is to introduce class labels as the context variables in the lifted higher-dimensional space (so supervised learning becomes unsupervised learning). We rigorously show that manifold untangling leads to linearly separable classifiers in the lifted space. To correct the inevitable overfitting, we consider the dual process of manifold untangling -- tangling or aliasing -- which is important for generalization. Using context as the bonding element, we construct a pair of manifold untangling and tangling operators, known as tangling-untangling cycle (TUC). Untangling operator maps context-independent representations (CIR) in low-dimensional space to context-dependent representations (CDR) in high-dimensional space by inducing context as hidden variables. The tangling operator maps CDR back to CIR by a simple integral transformation for invariance and generalization. We also present the hierarchical extensions of TUC based on the Cartesian product and the fractal geometry. Despite the conceptual simplicity, TUC admits a biologically plausible and energy-efficient implementation based on the time-locking behavior of polychronization neural groups (PNG) and sleep-wake cycle (SWC). The TUC-based theory applies to the computational modeling of various cognitive functions by hippocampal-neocortical systems.